Targeted DNA demethylation and methylation

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Albert Cheng,Aziz TAGHBALOUT,Nathaniel JILLETTE
WO2018053035A1
Publication year: 2018

Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.