While gene editing is currently the major approach used in CRISPR-based therapeutics, epigenetic editing – changing histone modifications, DNA methylation, […]

Our work led by Graduate Student Zukai Liu now online at Nucleic Acids Research! The CREST platform is a molecular […]

JACKIE software/database for gRNA designs is now published at The CRISPR Journal: https://doi.org/10.1089/crispr.2022.0042 For more information source code, database and […]

The paper⇒ Clow et al CRISPR-mediated multiplexed live cell imaging of nonrepetitive genomic loci with one guide RNA per locus https://www.nature.com/articles/s41467-022-29343-z Live-cell […]

Congrats to Aziz for his new publication at ACS synthetic biology! We created TALE-based in vivo DNA sensor components for […]

In a collaboration with Roel Verhaak laboratory, we applied Casilio’s imaging modules to label unique breakpoint sequence on ecDNAs, allowing […]

The Cheng lab will move to School of Biological and Health Systems Engineering (SBHSE) at Arizona State University (ASU) in Jan […]

The Cheng lab graduated the first PhD student Dr. Menghan Du! Dr. Du has an impressive publication record and has […]

Check out our paper using different NGS technologies to profile 3D genome interactome, epigenome, transcriptome, and genome-wide binding by C11orf95-RELA […]

Du, M.*, Jillette, N.*, Zhu, J.J., Li, S., Cheng, A.W. (2020) CRISPR Artificial Splicing Factors. Nature Communications 11:2973. doi: 1038/s41467-020-16806-4 Info page