• Bio/engineering

    Development of synthetic biology tools to edit the genome, epigenome and transcriptome

    In this branch of the research, we use designer DNA and RNA binding proteins (CRISPR/Cas, TALEN, Zinc finger, Pumilio) to construct and improve tools to achieve genome engineering, transcriptional regulation or epigenetic editing


  • Bio/informatics

    Development of bioinformatics tools and alogorithms

    We analyze parameters affecting genome editing to develop better genome editing design software. We also develop bioinformatics toolkits for analysis of sequencing data.


  • Biology

    Studies of epigenetics and transcriptomics in embryonic stem cells, cancer and metastasis

    We applies next-generation sequencing (NGS) technologies to interrogate epigenome and transcriptome in stem cells and cell models of diseases. We hope to functional validate targets using engineered molecular devices (based on e.g., CRISPR/Cas) we and others developed.