Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

EpigeneticsPhDEraStem Cells + Reprogramming
Dawlaty, M.M, Breiling, A., Le, Thuc, Barrasa, M.I., Raddatz, G., Gao, Q., Powell, B.E., Cheng, A.W., Faull, K.F., Lyko, F., Jaenisch, R.#
Developmental Cell 29(1):102-111
Publication year: 2014

SOX2 Co-occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

PhDEraStem Cells + Reprogramming
Lodato, M.A., Ng, C.W.*, Wamstad, J.A.*, Cheng, A.W., Thai, K.K., Faenkel, E., Jaenisch, R., Boyer, L.A.#
PLoS Genetics 9(2):e1003288
Publication year: 2013

Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs

PhDEraStem Cells + Reprogramming
Faddah, D.A., Wang, H., Cheng, A.W., Katz, Y., Buganim, Y., Jaenisch, R.#
Cell Stem Cell 13(1):23-29
Publication year: 2013

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

EpigeneticsPhDEraStem Cells + Reprogramming
Dawlaty, M.M., Breiling, A., Le, T., Raddatz, G., Barrasa, M.I., Cheng, A.W., Gao, Q., Powell, B.E., Li, Z., Xu, M., Faull, K.F., Lyko, F., Jaenisch R.#
Developmental Cell 24(3):310-323
Publication year: 2013

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

EpigeneticsPhDEraStem Cells + Reprogramming
Welstead, G.G., Creyghton, M.P., Bilodeau, S., Cheng, A.W., Markoulaki, S., Young, R.A., Jaenisch R.#
PNAS 109(32):13004-13009
Publication year: 2012

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase.

PhDEraRepresentativeStem Cells + Reprogramming
Buganim, Y.*, Faddah D.A.*, Cheng, A.W., Itskovich, E., Markoulaki, S., Gantz, K., Klemm S.L., van Oudenaarden A., Jaenisch, R.#
Cell 150(6):1209-1222
Publication year: 2012

Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors

PhDEraStem Cells + Reprogramming
Buganim, Y., Itskovich, E., Hu, Y.-C., Cheng, A.W., Ganz, K., Sarkar, S., Fu, D.D., Welstead, G., Page, D.C., Jaenisch, R.#
Cell Stem Cell 11(3):373-386
Publication year: 2012

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

PhDEraStem Cells + Reprogramming
Soldner, F., Laganière, J., Cheng, A.W., Hockemeyer, D., Gao, Q., Alagappan, R., Khurana, V., Golbe, L.I., Myers, R.H., Lindquist, S., Zhang, L., Guschin, D., Fong, L.K., Vu, B.J., Meng, X., Urnov, F.D., Rebar, E.J., Gregory, P.D., Zhang, H.S., Jaenisch, R.#
Cell 146(2):318-331
Publication year: 2011

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts

DiseasesPhDEraStem Cells + Reprogramming
Kim, J., Su, S.C., Wang, H., Cheng, A.W., Cassady, J.P., Lodato, M.A., Lengner, C.J., Chung, C.Y., Dawlaty, M.M., Tsai, L.H., Jaenisch R.#
Cell Stem Cell 9(5):413-419
Publication year: 2011

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

EpigeneticsPhDEraStem Cells + Reprogramming
Hanna J., Cheng, A.W., Saha K., Kim J.P., Lengner, C.J., Soldner, F., Cassady, J.P., Muffat, J., Carey, B.W., Jaenisch R.#
PNAS 107(20):9222-9227
Publication year: 2010

Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations

PhDEraStem Cells + Reprogramming
Lengner C.J., Erwin, J.A.*, Gimelbrant A.A.*, Cheng A.W., Guenther M.G., Welstead G.G., Alagappan R., Frampton M.F., Xu P., Powers D., Barrett C.B., Young R.A., Lee J.T., Jaenisch R.#, Mitalipova, M.#
Cell 141(5):872-883
Publication year: 2010

Metastable Pluripotent States in NOD-Mouse-Derived ESCs

PhDEraStem Cells + Reprogramming
Hanna, J.*, Markoulaki, S.*, Mitalipova, M., Cheng, A.W., Cassady, J.P., Staerk, J., Carey, B.W., Lengner, C.J., Foreman, R., Love, J., Gao, Q., Kim, J., Jaenisch, R.#
Cell Stem Cell 4(6):513-524
Publication year: 2009

Transgenic mice with defined combinations of drug-inducible reprogramming factors

PhDEraStem Cells + Reprogramming
Markoulaki, S.*, Hanna, J.*, Beard, C., Carey, B.W., Cheng, A.W., Lengner, C.J., Dausman, J.A., Fu, D., Gao, Q., Wu, S., Cassady, J.P. and Jaenisch, R.#
Nature Biotechnology 27(2):169-171
Publication year: 2008