Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling

Cheng LabCRISPR/Cas + TALENEpigeneticsRepresentativeRNA Splicing + RBPsSynthetic Biology + Genome Engineering
Albert W Cheng*#, Nathaniel Jillette*, Phoebe Lee, Dylan Plaskon, Yasuhiro Fujiwara, Wenbo Wang, Aziz Taghbalout, Haoyi Wang*#
Cell Research 26:254–257. doi:10.1038/cr.2016.3
Publication year: 2016

Muscleblind-like 1 (Mbnl1) regulates pre-mRNA alternative splicing during terminal erythropoiesis

PhDEraRepresentativeRNA Splicing + RBPs
Albert W Cheng*, Jiahai Shi*, Piu Wong*, Katherine L Luo, Paula Trepman, Eric T Wang, Heejo Choi, Christopher B Burge, Harvey F Lodish
Blood 124(4):598-610
Publication year: 2014

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

CRISPR/Cas + TALENPhDEraRepresentativeSynthetic Biology + Genome Engineering
Albert W Cheng*, Haoyi Wang*, Hui Yang, Linyu Shi, Yarden Katz, Thorold W Theunissen, Sudharshan Rangarajan, Chikdu S Shivalila, Daniel B Dadon, Rudolf Jaenisch
Cell Research (2013) 23:1163-1171
Publication year: 2013

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase.

PhDEraRepresentativeStem Cells + Reprogramming
Buganim, Y.*, Faddah D.A.*, Cheng, A.W., Itskovich, E., Markoulaki, S., Gantz, K., Klemm S.L., van Oudenaarden A., Jaenisch, R.#
Cell 150(6):1209-1222
Publication year: 2012

Alternatively spliced mRNA isoforms as prognostic indicators for metastatic cancer

Cancer + MetastasisPatentsPhDEraRepresentativeRNA Splicing + RBPs
Christopher Boyce BURGE, Wu Albert CHENG, John S. Condeelis, Frank B. Gertler, Maja H. OKTAY, Irina M. SHAPIRO
WO2012116248 A1
Publication year: 2012

Histone H3K27ac separates active from poised enhancers and predicts developmental state

EpigeneticsPhDEraRepresentative
Menno P Creyghton*, Albert W Cheng*, G Grant Welstead, Tristan Kooistra, Bryce W Carey, Eveline J Steine, Jacob Hanna, Michael A Lodato, Garrett M Frampton, Phillip A Sharp, Laurie A Boyer, Richard A Young, Rudolf Jaenisch
PNAS 107(50):21931–21936
Publication year: 2010

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

Cancer + MetastasisPhDEraRepresentativeRNA Splicing + RBPs
Irina M. Shapiro*, Albert W. Cheng*, Nicholas C. Flytzanis, Michele Balsamo, John S. Condeelis, Maja H. Oktay, Christopher B. Burge , Frank B. Gertler
PLoS Genet 7(8): e1002218
Publication year: 2010