Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling

Cheng LabCRISPR/Cas + TALENEpigeneticsRepresentativeRNA Splicing + RBPsSynthetic Biology + Genome Engineering
Albert W Cheng*#, Nathaniel Jillette*, Phoebe Lee, Dylan Plaskon, Yasuhiro Fujiwara, Wenbo Wang, Aziz Taghbalout, Haoyi Wang*#
Cell Research 26:254–257. doi:10.1038/cr.2016.3
Publication year: 2016

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

EpigeneticsPhDEraStem Cells + Reprogramming
Dawlaty, M.M, Breiling, A., Le, Thuc, Barrasa, M.I., Raddatz, G., Gao, Q., Powell, B.E., Cheng, A.W., Faull, K.F., Lyko, F., Jaenisch, R.#
Developmental Cell 29(1):102-111
Publication year: 2014

Tet1 is critical for neuronal activity-regulated gene expression and memory extinction

EpigeneticsPhDEra
Rudenko, A., Dawlaty, M.M., Seo, J., Cheng, A.W., Meng, J., Le, T., Faull, K.F., Jaenisch, R., Tsai, L.H.#
Neuron 79(6):1109-1122
Publication year: 2013

Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett Syndrome neurons

EpigeneticsPhDEra
Li, Y., Wang, H., Muffat, J., Cheng, A.W., Orlando, D.A., Loven, J., Kwok, S., Feldman, D.A., Bateup, H.S., Gao, Q., Hockemeyer, D., Mitalipova, M., Lewis, C.A., Heiden, W.G.V., Sur, M., Young, R.A., Jaenisch, R.#
Cell Stem Cell 13(4):446-458
Publication year: 2013

Combined Deficiency of Tet1 and Tet2 Causes Epigenetic Abnormalities but Is Compatible with Postnatal Development

EpigeneticsPhDEraStem Cells + Reprogramming
Dawlaty, M.M., Breiling, A., Le, T., Raddatz, G., Barrasa, M.I., Cheng, A.W., Gao, Q., Powell, B.E., Li, Z., Xu, M., Faull, K.F., Lyko, F., Jaenisch R.#
Developmental Cell 24(3):310-323
Publication year: 2013

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

EpigeneticsPhDEraStem Cells + Reprogramming
Welstead, G.G., Creyghton, M.P., Bilodeau, S., Cheng, A.W., Markoulaki, S., Young, R.A., Jaenisch R.#
PNAS 109(32):13004-13009
Publication year: 2012

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

EpigeneticsPhDEra
Dawlaty, M.M., Ganz, K., Powell, B.E., Hu, Y.C., Markoulaki, S., Cheng, A.W., Gao, Q., Kim, J., Choi, S.W., Page, D.C., Jaenisch, R.#
Cell Stem Cell 9(2):166-175
Publication year: 2011

Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes

EpigeneticsPhDEra
Wong, P., Hattangadi, S.M., Cheng, A.W., Frampton, G.M., Young, R.A., Lodish, H.F.#
Blood 118(16):E128-E138
Publication year: 2011

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

EpigeneticsPhDEraStem Cells + Reprogramming
Hanna J., Cheng, A.W., Saha K., Kim J.P., Lengner, C.J., Soldner, F., Cassady, J.P., Muffat, J., Carey, B.W., Jaenisch R.#
PNAS 107(20):9222-9227
Publication year: 2010

Histone H3K27ac separates active from poised enhancers and predicts developmental state

EpigeneticsPhDEraRepresentative
Menno P Creyghton*, Albert W Cheng*, G Grant Welstead, Tristan Kooistra, Bryce W Carey, Eveline J Steine, Jacob Hanna, Michael A Lodato, Garrett M Frampton, Phillip A Sharp, Laurie A Boyer, Richard A Young, Rudolf Jaenisch
PNAS 107(50):21931–21936
Publication year: 2010