CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells

CRISPR/Cas + TALENSynthetic Biology + Genome Engineering
Liu X, Zhang Y, Cheng C, Cheng AW, Zhang X, Li N, Xia C, Wei X, Liu X, Wang H
Cell Research doi: 10.1038/cr.2016.142
Publication year: 2017

Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling

Cheng LabCRISPR/Cas + TALENEpigeneticsRepresentativeRNA Splicing + RBPsSynthetic Biology + Genome Engineering
Albert W Cheng*#, Nathaniel Jillette*, Phoebe Lee, Dylan Plaskon, Yasuhiro Fujiwara, Wenbo Wang, Aziz Taghbalout, Haoyi Wang*#
Cell Research 26:254–257. doi:10.1038/cr.2016.3
Publication year: 2016

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease

CRISPR/Cas + TALENPostDocEraSynthetic Biology + Genome Engineering
Wenning Qin, Stephanie L Dion, Peter M Kutny, Yingfan Zhang, Albert Cheng, Nathaniel L Jillette, Ankit Malhotra, Aron M Geurts, Yi-Guang Chen, Haoyi Wang
Genetics. 115.176594
Publication year: 2015

Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal

CRISPR/Cas + TALENPatentsSynthetic Biology + Genome Engineering
Rudolf Jaenisch, Haoyi WANG, Hui Yang, Chikdu SHIVALILA, Wu Albert CHENG
WO2014172470
Publication year: 2014

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

CRISPR/Cas + TALENPhDEra
Wu, X., Scott, D.A., Kriz, A.J., Chiu, A.C., Hsu, P.D., Dadon, D.B., Cheng, A.W., Trevino, A.E., Konermann, S., Chen, S., Jaenisch, R., Zhang, F., Sharp, P.A.#
Nature Biotechnology 32(7):670-676
Publication year: 2014

CRISPR-Cas9 genome editing of a single regulatory element nearly abolishes target gene expression in mice

CRISPR/Cas + TALENPostDocEraSynthetic Biology + Genome Engineering
Han Y, Slivano OJ, Christie CK, Cheng AW, Miano JM.
Arterioscler Thromb Vasc Biol. 35(2):312-315
Publication year: 2014

TALEN-mediated editing of the mouse Y chromosome

CRISPR/Cas + TALENPhDEraSynthetic Biology + Genome Engineering
Wang, H.*, Hu, Y.C.*, Markoulaki, S., Welstead, C.G., Cheng, A.W., Shivalila, C.S., Pyntikova, T., Dadon, D.B., Voytas, D.F., Bogdanove, A.J., Page, D.C., Jaenisch, R.#
Nature Biotechnology 31(6):530-532
Publication year: 2013

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

CRISPR/Cas + TALENPhDEra
Yang, H.*, Wang, H.*, Shivalila, C.S.*, Cheng, A.W., Shi, L., Jaenisch, R.#
Cell 154(6):1370-1379
Publication year: 2013

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

CRISPR/Cas + TALENPhDEra
Wang, H.*, Yang, H.*, Shivalila, C.S.*, Dawlaty, M.M., Cheng, A.W., Zhang, F., Jaenisch, R#
Cell 153(4):910-918
Publication year: 2013

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

CRISPR/Cas + TALENPhDEraRepresentativeSynthetic Biology + Genome Engineering
Albert W Cheng*, Haoyi Wang*, Hui Yang, Linyu Shi, Yarden Katz, Thorold W Theunissen, Sudharshan Rangarajan, Chikdu S Shivalila, Daniel B Dadon, Rudolf Jaenisch
Cell Research (2013) 23:1163-1171
Publication year: 2013